Member Institutions:

• Bowling Green State U.
• Cleveland State U.
• Kent State U.
• Medical College of Ohio
• Miami U.
• The Ohio State U.
• Ohio U.
• University of Cincinnati
• University of Toledo
• Wright State U.
• Youngstown State U.

Donald Lindmark Department of Biological, Geological and Environmental Sciences Cleveland State Univerisity Cleveland, Ohio 44115 Phone (216) 687-2398 email d.lindmark@csuohio.edu

Research Interests

My research centers on two areas:

1. improvement in grape and wine production, based on studies of grape and yeast speciation, cold resistance genes in grapes, natural yeasts on grapes, in the winery, and yeast population and chemical changes during spontaneous fermentation. The goal is to improve the quality of Ohio wines.
2. the cell and molecular biology of anaerobic protozoan parasites with emphasis on trichomonads, Giardia, Cryptosporidium and Hexamita. I am investigating their subcellular organization, organelle (hydrogenosome) biogenesis, carbohydrate and lipid metabolism, arginine metabolism, protease activities and differentiation (excystment and excystation of Giardia and Cryptosporidium) utilizing techniques of molecular biology, cell biology and enzymology.

Selected References

• Macechko, P.T., Steimle, P.A., Lindmark, D.G., Erlandsen, S.L. and Jarroll, E.L. Galactosamine synthesizing enzymes are induced when Giardia encyst. Mol. Biochem. Parasitol., 56, 301-310 (1992).
• Paget, T.A., Kelly, M.L., Jarroll, E.L., Lindmark, D.G. and Lloyd, D.L. The effects of oxygen on fermentation in Giardia lamblia. Mol. Biochem. Parasitol., 57, 65-72 (1993).
• Ellis, J.E., Lindmark, D.G., Williams, A.G. and Lloyd, D. Polypeptides of hydrogenosome-enriched fractions from rumen ciliate protozoa and trichomonads: Immunological studies. FEMS Microbiol. News Letters, 117, 211-216 (1994)
• Yarlett, N., Lindmark, D.G., Goldberg, B., Moharrami, M.A., and BACCHI C.J. Subcellular localization of the enzymes of the arginine dihydrolase pathway in Trichomonas vaginalis and Tritrichomonas foetus. J. Euk. Microbiol. 41, 554-559 (1994).
• Singh, B.N., Beach, D.H., Lindmark, D.G. and Costello, C. E. Identification of the lipid moiety and further characterization of the novel lipophosphoglycan-like glycoconjugates of Trichomonas vaginalis and Tritrichomonas foetus. Arch. Biochem and Biophys. 309, 273-280 (1994).
• Malek, S., Jarroll, E.L., Wade, S., Schaaf, S. and Lindmark, D.G. Detection of selected enzyme activities in Cryptosporidium parvum. J. Euk. Microbiol. 43, 82S (1996).
• Steimle, P., Lindmark, D.G. and Jarroll, E.L. Purification and characterization of encystment-induced glucosamine 6-phosphate isomerase in Giardia. Mol. Biochem. Parsitol. 84, 149-153 (1997).
• Phillips, N.F.B., LI, Z., and Lindmark, D.G. Isolation of a pyrophosphate-dependant phosphofructokinase from Hexamita inflata. Mol. Biochem. Parasitol. 90, 377-380 (1997).
• Bulik, D.A., Lindmark, D.G. and Jarroll, E.L. Purification and characterization of UDP-N-Acetylglucosamine pyrophosphorylase from encysting Giardia. Mol. Biochem. Parsitol. 95, 135-139 (1998).

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